Faculty of Medicine researchers receive over $36 million through CIHR project grants

Faculty of Medicine researchers have received over $36 million in funding through the Canadian Institutes of Health Research (CIHR) Project Grants: Spring 2022 competition.

In total, this competition approved 405 research grants, plus two transition grants, for a total investment of approximately $325 million. In addition, 61 priority announcement grants were funded for a total amount of $10,779,207 and 16 additional awards were awarded for a total of $1,060,000.

Principal investigators of the Faculty of Medicine and their projects:

Project grants

Purang Abolmaesumi, School of Biomedical Engineering and Michael Y. Tsang and Teresa S. TsangDepartment of Cardiology
Automatic Aortic Stenosis Assessment with Point-of-Care Ultrasound

Francois BenardDepartment of Radiology
Development of second-generation radiopharmaceuticals targeting CXC chemokine receptor 4 for hematological cancer imaging and therapy
*Conditional funding at time of publication

Inanc Birol, Department of Medical Genetics
Assembly and annotation of genomes, transcriptomes and metagenomes

Jade BoydDepartment of Medicine
An intersectional inquiry into women’s experiences of overlapping overdoses and COVID-19 public health crises

Lara BoydDepartment of Physiotherapy
Gamifying neuro rehabilitation: can we predict who will benefit?

Christopher CarlstenSchool of Public and Population Health
Traffic-related air pollution, inhaled corticosteroids and host defense response in COPD

Mark S. CembrowskiDepartment of Cellular and Physiological Sciences
A specialized neural circuit representing novelty on behavioral time scales

Anne Marie CraigDepartment of Psychiatry
Targeting synaptic organizers in neuropsychiatric disorders

Peter CullisDepartment of Biochemistry and Molecular Biology
Development of LNP/mRNA systems for the direct transfection and generation of functional chimeric antigen receptor (CAR) T cells in vivo for the treatment of blood and other cancer cell types
*Conditional funding at time of publication

Laura E. EvginDepartment of Medical Genetics
Harnessing TCR Responsiveness to Improve CAR T Therapy

Daniel GoldowitzDepartment of Medical Genetics and Paul Pavlidis, Department of Psychiatry
Pax6 regulation of glutamatergic lineages in cerebellar development

David J. GranvilleDepartment of Pathology and Laboratory Medicine
New mechanisms and therapeutic approach for aging-related pruritus

Ethan J. GreenblattDepartment of Biochemistry and Molecular Biology
Determine the role of FMRP complexes in the expression of autism-relevant genes

Pamela A. HoodlessDepartment of Medical Genetics and School of Biomedical Engineering
Hepatic lineage transcriptional drivers
*Conditional funding at time of publication

Aly KarsanDepartment of Pathology and Laboratory Medicine
Clonal interactions in myeloid malignancy

Aly KarsanDepartment of Pathology and Laboratory Medicine
Role of SASH1 in the generation of hematopoietic stem cells

Paul W. KershawSchool of Public and Population Health
Application of Social/Medical Expenditure Ratio Research to Federal and Provincial Budget Allocations Across Departments

Wan L. LamDepartment of Pathology and Laboratory Medicine
Targeting the lung microbiome to develop early detection and intervention strategies for lung cancer
*Conditional funding at time of publication

Blair R. LeavittDepartment of Medical Genetics
Lipid nanoparticle-mediated delivery of CRISPR/Cas9 gene editing for neurological disorders.

Peter C. Leung and Alexandre G. BeristainDepartment of Obstetrics and Gynecology
Role of BMP2 signaling at the maternal-fetal interface
*Conditional funding at time of publication

Kuo-Shyan LinDepartment of Radiology
Next-generation radiopharmaceuticals targeting GRPRs with improved in vivo stability and minimized pancreatic uptake

Sarka LisonkovaDepartment of Obstetrics and Gynecology
Health and neurodevelopmental trajectories of preterm and term children and adolescents

Hong Shen MaSchool of Biomedical Engineering
Behavior-Based Cell Separation to Interrogate Host Cell Heterogeneity in CAR-T Cell Therapies

Amee R. EatsSchool of Population and Public Health, and Amin R. JaverDepartment of Surgery
SinoNasal Microbiota Transfer (SNMT) for treating chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial

Deborah M. SilverDepartment of Obstetrics and Gynecology
A study of dose reduction of the nine-valent HPV vaccine in women living with HIV

Ivan R. NabiDepartment of Cellular and Physiological Sciences
Role of MERCs and mitophagy in cancer progression

William J. PanenkaDepartment of Psychiatry, Thalia S. FieldDepartment of Medicine and Cheryl L WellingtonDepartment of Pathology and Laboratory Medicine
Traumatic brain injury and small cerebral vessel disease in a cohort of vulnerable housed people, a prelude to early neurodegeneration and dementia

Jacqueline A. QuandtDepartment of Pathology and Laboratory Medicine
Targeting inflammatory and neurodegenerative pathways relevant to progression in the NR1H3 (LXRA) R415Q model of primary progressive multiple sclerosis

alexander rauscherDepartment of Pediatrics
Quantitative sensitivity mapping from clinical phase data

Elizabeth J. RideoutDepartment of Cellular and Physiological Sciences
Understanding gender differences in neural control of fat storage and breakdown throughout the body

Amy L. SalmonSchool of Public and Population Health
Family Matters: involving loved ones to prevent overdose deaths in semi-urban and rural communities

Julia SchmidtDepartment of Occupational Science and Occupational Therapy
Peers Actively Involved in Rehabilitation: Transforming Rehabilitation After Traumatic Brain Injury (PAIR TBI)

Chun Y. Seow, Department of Pathology and Laboratory Medicine
Mechanisms underlying the bronchodilator effect of deep inspiration in health and asthma: from airway smooth muscle to whole lung

Nika ShakibaSchool of Biomedical Engineering
A bioengineering platform to promote safe cell therapies
*Conditional funding at time of publication

Amanda K. Slaunwhite and Tonia L.NichollsSchool of Population and Public Health and Christian G. Schütz, Department of Psychiatry
An Evaluation of Health, Criminal Justice and Service Utilization Outcomes of the Ministry of Health with Responsibility for Health Care Services in BC Prisons (PRISM-BC)

Patricia M. SpitalSchool of Public and Population Health
The Cedar Project: Strengthening Our Spirit Intervention for Indigenous people who use drugs in two Canadian cities

John A. StaplesDepartment of Medicine
Overdose after discharge from hospital against medical advice

Aline Talhouk, Michael S. Anglesio and Deborah M. SilverDepartment of Obstetrics and Gynecology and Anna Tinker, Department of Medicine
Digital self-monitoring and self-testing for early detection of endometrial cancer

Michael UnderhillDepartment of Cellular and Physiological Sciences and School of Biomedical Engineering
Fate and function of mesenchymal progenitors in the tumor microenvironment of medulloblastoma

Michael UnderhillDepartment of Cellular and Physiological Sciences and School of Biomedical Engineering
Mesenchymal progenitors in liver fibrosis – quiescence as a therapeutic target

Philippe Van PetegemDepartment of Biochemistry and Molecular Biology
Mechanisms of regulation of voltage-gated calcium channels

Philippe Van PetegemDepartment of Biochemistry and Molecular Biology
Structural and Functional Investigation of Junctophilins in Health and Disease

Paul Yoon, Michael S. Anglesio, Ali Bedaiwy Mohamedand Aline TalhoukDepartment of Obstetrics and Gynecology
Clinical biomarker predictors of outcome after endometriosis surgery

Priority Announcement Grants

Priority Announcement: Epigenetics/Epigenomics in Human Health or Disease
Donald Sin and Janice LeungDepartment of Medicine
Epigenetic Blood Biomarkers of Age and Health Outcomes in COPD

See the full list of recipients here.

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